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Molecular Basis of Inheritance Test - 57

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Molecular Basis of Inheritance Test - 57
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  • Question 1
    1 / -0
    Melting temperature for double stranded molecules are converted into single stranded molecules. Which one of the following DNA will have the highest melting temperature?
    Solution
    The stability of the DNA segment depends on the type of bases. If the DNA is rich in cytosine and guanine, then the DNA is considered to be more stable and have the highest melting point. The more the number of cytosine and guanine, the more are the hydrogen bonds and more stable is the DNA.
    Thus, the correct answer is option B. 
  • Question 2
    1 / -0
    Transfer RNA (tRNA)
    Solution
    The molecular structure of T -Rna can be explained by a cloverleaf model which was proposed by Holley. According to this model, a single polynucleotide chain is folded upon itself to due to which 3' and 5' end come close to each other and the 3' end has CCA nucleotides and G at the fifth end. This model shows the presence of three arms namely DHU arm, a middle arm, TPsi C arm. These arms have loops at their terminal end such as aminoacyl loop, anticodon loop, ribosomal binding loop. It also shows the presence of small lump called as a variable lobe or extra arm. Thus the correct answer is option B.
  • Question 3
    1 / -0
    In a random DNA sequence, what is the lowest frequency of encountering a stop condon?
    Solution
    UAA, UAG and UGA are stop codons. These stop codons signal the termination of translation which is the process of protein synthesis. In a random DNA sequence stop codons occur at a frequency of around 1 in 20. Thus the correct answer is option A.
  • Question 4
    1 / -0
    Desert temperature often varies between  0 to 50$$^o$$C. The DNA polymerase isolated from a camel living in the desert will be able to synthesize DNA most efficiently at
    Solution
    The camels are the dessert animals which belong to the group of mammals. The mammals are able to maintain the temperature of the body constant. The body temperature is maintained optimum at 37$$^o$$ C and this is the temperature at which all the reactions takes place with the optimum activity of the enzymes. So, the enzyme DNA polymerase will synthesize the DNA most effectively at this temperature.
    Thus, the correct answer is option B. 
  • Question 5
    1 / -0
    Watson and Crick model of DNA is a
    Solution
    • The model of DNA was given by Watson and Crick in the year 1953. It is the hereditary molecules that are responsible for carrying the characters from parents to offspring.
    • The DNA is in the $$B$$-form that shows left-handed coiling.
    • The  spiral length is $$34 \mathring { A } $$ and its diameter of $$20 \mathring { A } $$. One spiral turn has $$10$$ base pairs. 
      Thus the correct answer is option A.

  • Question 6
    1 / -0
    A new life from discovered on a distant has a genetic code consisting of five unique nucleotides and only one stop codon. If each codon has four bases, what is the maximum number of unique amino acids this life from can use?
    Solution
    As it is given in the question each codon has four bases, As the new life form has five unique nucleotides there are 5 possible combinations for the first position in the codon. This is repeated for all codons. As there are 4 codons using probability 5x5x5x5= 625 which can be approximated to 624. Thus the correct answer is option A.
  • Question 7
    1 / -0
    According to the original model of DNA, as proposed by Watson and Crick in 1953. DNA is a
    Solution
    • The model of DNA was given by Watson and Crick in the year 1953. It is the hereditary molecules that are responsible for carrying the characters from parents to offspring. 
    • The DNA is in the $$B$$-form that shows right-handed coiling. The spiral length is $$34 \mathring { A } $$ and its diameter of $$20 \mathring { A } $$. One spiral turn has 10 base pairs. 
    • Thus, the correct answer is option A.

  • Question 8
    1 / -0
    During replication of DNA, the two strands of the double helix are separated from each other under the influence of enzyme
    Solution
    Rep protein is the repetitive extragenic palindromic protein that serves to unwind the DNA to initiate the replication. SSB proteins serve to stabilise the unwound DNA by preventing the formation of H-bonds between the base pairs of the ssDNA. DNA polymerase elongates the primer by addition of deoxyribonucleotides. Initiator proteins serve to recognise the ori followed by formation of primosome. 
    So, the correct answer is option A.
  • Question 9
    1 / -0
    A phenomenon where the third base of t-RNA at its 5' end can pair with a complementary base of m-RNA is called
    Solution
    The genetic code is degenerate which means that one codon can specify more than one amino acid. For example, GAA and GAG both specify same amino acid which is glutamic acid and not any other amino acid. Degenerate codons differ in their third positions. 
    There are 64 codons and only 20 amino acids. Due to this the redundant codons which specify the same amino acid are related to each other by a sequence. For example, leucine is specified by codons CUU, CUA, CUC and CUG. All the codons are same except the ones at third position. The third position is known as wobble position which can change but still specify the same amino acid.
    Genetic code is universal which means that it is same for all organisms raging from bacteria to man except certain bacteria, mitochondria and protists where minor variations can be seen. 
    Genetic code is collinear which means that the sequence of amino acids in a polypeptide chain corresponds to the sequence of bases in DNA that codes for it. Any change in codon will change the amino acid in polypeptide. 
    Thus, the correct answer is option A. 
  • Question 10
    1 / -0
    There are 64 codons in the genetic dictionary as
    Solution
    There are 64 colons as genetic code is triplet. Three adjacent bases, termed a codon specify one amino acid. This can only account for the 20 amino acids. Thus in a triplet codon, the four bases would specify a total of 64 amino acids. Thus, the correct answer is option B. 
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