Molecular Basis of Inheritance Test

Result

Molecular Basis of Inheritance Test - 3

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Weekly Quiz Competition

Question 1
4 / -1

First experimental proof for semi-conservative DNA replication was shown in

A
Streptococcus pneumoniae

B
Escherichia coli

C
Neurospora crassa

D
Rattus rattus

Solution

Mathew Meselson and Franklin Stahl (1958) conducted various experiments using isotopically labelled DNA of Escherichia oli to provide evidence in favour of semije mode of DNA replication. various experiments Escherichia coli to on conservative mode notes the renlisation of DNA replication.
Question 2
4 / -1

DNA replication takes place at ________ phase of the cell cycle

A
G₁

B
S

C
G₂

D
M

Solution

In eukaryotes, the replication of DNA takes place at S-phase of the cell cycle. The replication of DNA and cell division cycle should be coordinated. A failure in cell division after DNA replication results into chromosomal anomaly.
Question 3
4 / -1

Select the incorrect statement regarding DNA replication.

A
Leading strand is formed in 5'→3' direction

B
Okazaki fragments are formed in 5'→3' direction

C
DNA polymerase catalyses polymerisation in 5'→3' direction

D
DNA polymerase catalyses polymerisation in 3'→5' direction

Solution

Synthesis of DNA by DNA polymerases occurs only in 5'→3' direction. One strand called leading strand , is copied in the same direction as the unwinding helix. The other strand is known as lagging strand. Replication of lagging strand is in a dicontinuous way , and in the direction of growth of lagging stand is 3'→5' though in short segments of DNA which are always in the 5'→3' direction. These short segments are called Okazaki fragments joined together by the action od DNA ligase.
Question 4
4 / -1

Select the correct match of enzyme with its related function

A
DNA polymerase - Synthesis of DNA Strands

B
Helicase - Unwinding of DNA helix

C
Ligase - Joins together short DNA segments

D
All of these
Question 5
4 / -1

Other than DNA polymerase, which of the following enzymes involved in DNA synthesis?

A
Topoisomerase

B
Helicase

C
RNA primase

D
All of these

Solution

Process of DNA synthesis whereby a parent DNA molecule is faithfully copied , giving rise to two identical daughter molecules id called DNA replication. In DNA synthesis, DNA polymerase plays an important role having the capability to elongate an existing DNA strand but cannot initiate the synthesis. So, the synthesis is initiated with the help of RNA primer formed by RNA primase. RNA primase synthesises the short RNA primer of about 10 nucleotides that is elongated by DNA polymerase to form an Okazaki fragment of DNA during DNA replication. Helicase unzips the two strands of DNA and toposiomerase reduces the coiling tension developed due to the unwinding of the two strands of DNA and topoisomerase reduces the coiling tension developed due to the unwinding of the two strands.